WELLF Science Lab

On Creatine, and Performance Confectionery.

The end of the supplement era.

The chemistry, manufacturing, and behavioural science behind the first creatine monohydrate sweet that’s both chemically stable and a daily treat[1] , engineered to sustain the everyday athlete across body, mind, and every stage of life.

F/0.1 WELLF 001
Fig. 0.1 The subject under study · creatine sweet, Watermelon Sours formulation.
Written by
Jabed Amin, Founder
References
16 peer-reviewed studies
01 · Abstract p. 02

TL;DR.

The thesis in six panels. If you read nothing else, read these.

Problem
70% never reordered

Two problems. One trade-off.[1]

Supplements feel like medicine, so people quit. Gummy products fail the science or taste bad.

Insight
Stability. + Experience.

The first creatine sweet that doesn’t compromise: clinically dosed, chemically stable, and something people actually want to take every day.

Hypothesis

Pleasure drives consistency.

When the daily dose tastes like a treat, people take it consistently. Taking it stops being a discipline problem, and the physiological benefits compound automatically.

Formula
5g Creatine monohydrate, microencapsulated.
+ B-matrix co-factors (B3 / B5 / B6 / B12).
+ Proprietary staged-pulse manufacturing.

One sweet. Three engineering responses to the two-friction problem.

Result
+20%
Strength
+35%
Recovery
+24%
Cognition
+40%
PCr fuel

Measured outcomes from the underlying creatine literature. Each cited in §02.

Citations
16 peer-reviewed studies

Cited inline.

Full bibliography at §06.

02 · Effects of Creatine p. 03
The body of evidence

Performance & cognition.

Four systems. Hundreds of studies. The most researched performance compound in sports science, measured against everything that matters for everyday athletes.

02.1 · Strength

Stronger, faster.

over 8–12 weeks of resistance training.

+50% Greater improvement in upper body strength vs placebo, and +33% lower body.

Source · Rawson & Volek 2003

Fig 2.1 · Strength gain over 8–12 weeks SourceRawson & Volek 2003
↑ % STRENGTH GAIN 40% 30% 20% 10% 0% 16% 24% UPPER BODY +50% greater 24% 32% LOWER BODY +33% greater
Training only (placebo) Creatine + Training
LEAN MASS

Engineered hypertrophy.

Training alone increased lean tissue by 3.1% over 12 weeks. Creatine + training doubled it to 6.3%. The hypertrophy advantage compounds with every session.

02.2 · Output

Engine, power.

maximising high-intensity work capacity.

+20% +20% greater work capacity in high-intensity intervals vs placebo.

Source · Branch 2003 · meta-analysis

Fig 2.2 · The fatigue curve SourceGreenhaff et al. 1993
↑ POWER OUTPUT (W) 900 800 700 600 500 1 2 3 4 5 6 7 8 9 10 SPRINTS · REPETITIONS
Training only (placebo) Creatine + Training
Higher intensity +16%

Ventilatory threshold.

Elevates the lactate-clearance ceiling, so you can sustain higher-intensity work before gassing out.

Source · Graef et al. 2009 · JISSN
Longer duration +54%

Muscle fuel reserves.

Super-compensates muscle glycogen when co-ingested with carbs, extending time-to-exhaustion in long efforts.

Source · Roberts et al. 2016 · Amino Acids
Elevated peak +7%

Critical power.

Raises the maximum sustainable pace ceiling: the highest power you can hold without exhaustion in time-trial efforts.

Source · Kendall et al. 2009 · JSCR
02.3 · Recovery

Recover, quick.

less cellular damage, so you bounce back sooner.

~84% Approximately 84% reduced muscle damage at 48 hours post-exercise vs placebo.

Source · Cooke et al. 2009 · JISSN

Fig 2.3 · Plasma CK at 48 hours SourceCooke et al. 2009
MUSCLE DAMAGE MARKERS • PLASMA CK TRAINING ONLY CREATINE + TRAINING −84% lower damage markers.

Each dot = one creatine kinase enzyme leaked from a damaged muscle cell into the bloodstream.

Training only (placebo) Creatine + Training
Force preserved
+21%

Strength retained.

Holds more of your peak isometric force during the recovery window. The next session starts from a higher floor, not from scratch.

Source · Cooke et al. 2009 · JISSN
Systemic load
34–61%

Stress response dampened.

Blunts the cytokine alarm the body fires after hard training (TNF-α −34%, PGE₂ −61%): quieter systemic stress, shorter recovery hangover.

Source · Bassit et al. 2008 · Amino Acids
02.4 · Command Centre

Command, centre.

sharper cognitive output under sustained load.

+16% +16% greater neural efficiency during cognitive load vs placebo.

Source · Watanabe et al. 2002 · Neurosci Res

Fig 2.4 · Cognitive performance under sleep loss SourceMcMorris et al. 2006
↑ COGNITIVE PERFORMANCE (% BASELINE) 100% 90% 80% 70% 60% Sharper at 24hr. 0H 6H 12H 24H HOURS · SLEEP DEPRIVATION
Training only (placebo) Creatine + Training
Endurance under load
24hr

Sleep loss resilience.

Performance held near baseline across 24hr sleep deprivation. Reaction time, working memory, mood, all preserved where placebo declined.

Source · McMorris et al. 2006 · Psychopharmacology
Working memory
+21%

More digits held.

Backward Digit Span recall jumped from ~7 to ~8.5 digits: a 21% capacity gain on the gold-standard working-memory test.

Source · Rae et al. 2003 · Proc R Soc B

— WELLF LAB NOTES

Stay close to the science.

Occasional notes from the lab. New research, behind the engineering, no spam.

03 · Hypothesis p. 04
The Consistency Hypothesis

Engineering Momentum.

Progress is non-linear. Most people quit their supplements within the first few weeks, because the industry has a dual-friction problem, and no brand has solved both axes at once.

The Problem

Two friction points. Both unsolved. They multiply.

Axis 1 Behavioural.

Sensory aversion

Supplements feel like medicine, so people quit them inside a fortnight.

Why 70% never get reordered.

Axis 2 Physiological.

Systemic fatigue

The everyday athlete is prone to fatigue, juggling training, work, and all of life's other commitments, making supplementation crucial.

Why progress plateaus.

The Solution

Solve the behavioural axis first. The physiology compounds.

Fig 3.1 · The Momentum Loop

Make it desire, not duty.

01

Desire.

Make it something they want.

The daily dose feels like a treat. Sensory aversion solved at the molecular level.

triggers ↓
02

Consistency.

Desire produces consistency.

The two-week drop-off vanishes when people genuinely look forward to the daily ritual.

enables ↓
03

Compounding.

Consistency unlocks compounding.

Creatine and the B-matrix were designed to compound. Most people just never give the biology the chance.

produces ↓
04

Progress.

Progress becomes inevitable.

Not effortful. Not optional. Inevitable, because the inputs run on autopilot.

↺ loops back
The thesis, compressed
Who needs discipline
when you have desire?

WELLF, founding principle

04 · The Formula p. 05
A complete formula for the everyday athlete

The complete formula.

Everyday people doing extraordinary things, running mixed loads of work, training, and life all at once. WELLF engineered a formula built around them: creatine drives your performance, while the B-matrix keeps the conditions optimal for energy metabolism and resilience to load.

04.1 · The Performance Compound
Creatine Monohydrate.
5g Per daily dose

The most-studied compound in sports nutrition.

Drives ATP recycling across muscular and neural systems. Phosphocreatine rebuilds ATP in milliseconds during high-intensity effort and sustained cognitive load. The clinical-standard form, at the dose the literature converges on.

Strength Power Recovery Cognition

Source · Kreider et al. 2017 · ISSN Position Stand

Fig 4.1 · Muscle creatine saturation SourceKreider et al. 2017
↑ MUSCLE CREATINE (% SATURATION) 100% 90% 80% 70% 60% SATURATED • ≥95% Saturated by Day 28. DAY 0 DAY 7 DAY 14 DAY 21 DAY 28 DAYS · DAILY 5g PROTOCOL
B3 20mg Niacinamide
NAD⁺ Energy Replenishment

"Stop the slow energy decline that comes with age."

Direct precursor to NAD⁺, the electron carrier driving mitochondrial ATP production. NAD⁺ declines ~40–50% by age 45 while demand stays high. Tops up the precursor pool the body uses to make energy.

Energy
Source · Bogan & Brenner 2008 · Annu Rev Nutr
B5 5mg Ca D-Pantothenate
Acetyl-CoA Supply

"Feed sustained energy and brain-muscle signal."

Precursor to Coenzyme A, which feeds the TCA cycle for sustained energy and builds acetylcholine, the neurotransmitter that fires both muscle contraction and cognitive focus.

Stamina
Source · Tahiliani & Beinlich 1991 · Vitam Horm
B6 5mg Pyridoxine HCl
GABA + Methyl Support

"Build the brain's calm. Recover between sessions."

Essential cofactor for GABA synthesis (the brain's calming neurotransmitter) and the transsulfuration pathway that supports creatine's own methylation infrastructure.

Recovery
Source · Stover & Field 2015 · Adv Nutr
B12 10µg Cyanocobalamin
Neurotoxin Clearance

"Long-term brain protection from neurotoxic buildup."

Drives methionine synthase, clearing neurotoxic homocysteine before it accumulates in the brain. The body generates this byproduct continuously through methylation; B12 keeps it in check.

Neuroprotection
Source · Smith & Refsum 2016 · Annu Rev Nutr

Engineered for mind and body under sustained load.
For the busy, ambitious everyday athletes doing it all.

05 · Engineered for stability p. 06
How WELLF keeps creatine intact

Engineered for stability.

Creatine is fragile. In water it slowly converts to creatinine, the inactive byproduct. Heat accelerates the reaction. Acid accelerates it further. WELLF engineers around all three.

Particle-level shielding

Micro-encapsulation.

We micro-encapsulate our creatine so at a particle level the molecule stays shielded from the aqueous environment inside the sweet, from manufacturing temperatures, and from the slow degradation that hits unprotected creatine in any wet format. It stays creatine, until it hits your gut.

Below the degradation threshold

Low-temperature processing.

Creatine starts converting to creatinine at 50–70°C. We process below that threshold, all the way through, preserving the active compound from raw ingredient to finished sweet.

Where creatine stays stable

pH-balanced matrix.

In an acidic environment (pH 3.5) unprotected creatine loses 21% in 3 days. At neutral-to-alkaline pH it stays stable. We engineer the formulation toward the safe zone.

05.4 · Quality & Third-Party Testing

Third-party certified.

Every batch independently tested for creatine identity, purity, and dose, using the pharmaceutical-industry's gold-standard method.

Eurofins analytical report header for WELLF Nutraceuticals creatine sample, certificate AR-26-SU-064916-02

The supplement industry produces creatine gummies by adding the labelled dose to the formula, without verifying what survives production or remains bioavailable in the finished product. WELLF invested in R&D to solve creatine's instability, engineering a proprietary process, third-party verified by Eurofins.

  1. The supplement industry adds the labelled dose to the formula, without verifying what survives, or what stays bioavailable.
  2. WELLF stabilised creatine against the four conditions that destroy it elsewhere: moisture, heat, acidic pH, and time.
  3. Third-party verified by Eurofins. Every batch.
Official Testing Partner · Eurofins

Independently verified.

A world-leading analytical lab, not us, has tested our sweets and confirmed the labelled dose survives production: a full 5.0g of creatine monohydrate in every 24g serving of four sweets, stable and intact in the finished product.

Method · USP Creatine Monograph (Modified) · HPLC

Each peak is a compound. HPLC identifies creatine by its retention time and UV signature, confirming the labelled dose.

— ALL THE SCIENCE

All the science. In a sweet.

Try one tub. No commitment, no auto-renew.

— 06 · REFERENCES p. 07
16 peer-reviewed studies · DOIs included

Our research foundation.

WELLF evaluated sixteen peer-reviewed studies that form the basis of its research and development, from initial formulation through to the finished product. Each is linked below at its publisher of record.

  1. MobiLoud. 2026. “What’s a Good Repeat Customer Rate in Ecommerce? Latest Benchmarks for 2026.” Health and supplements category repeat customer rate: ~29%. Roughly seven in ten supplement customers do not make a second purchase.

    MobiLoud Ecommerce Benchmarks; Source

  2. Rawson ES, Volek JS. 2003. “Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance.

    J Strength Cond Res; 17(4):822–831. DOI

  3. Branch JD. 2003. “Effect of creatine supplementation on body composition and performance: a meta-analysis.

    Int J Sport Nutr Exerc Metab; 13(2):198–226. DOI

  4. Greenhaff PL, Casey A, Short AH, Harris R, Söderlund K, Hultman E. 1993. “Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.

    Clin Sci (Lond); 84(5):565–571. DOI

  5. Cooke MB, Rybalka E, Williams AD, Cribb PJ, Hayes A. 2009. “Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals.

    J Int Soc Sports Nutr; 6:13. DOI

  6. Graef JL, Smith AE, Kendall KL, Fukuda DH, Moon JR, Beck TW, et al. 2009. “The effects of four weeks of creatine supplementation and high-intensity interval training on cardiorespiratory fitness: a randomized controlled trial.

    J Int Soc Sports Nutr; 6:18. DOI

  7. Roberts PA, Fox J, Peirce N, Jones SW, Casey A, Greenhaff PL. 2016. “Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans.

    Amino Acids; 48(8):1831–1842. DOI

  8. Kendall KL, Smith AE, Graef JL, Fukuda DH, Moon JR, Beck TW, et al. 2009. “Effects of four weeks of high-intensity interval training and creatine supplementation on critical power and anaerobic working capacity in college-aged men.

    J Strength Cond Res; 23(6):1663–1669. DOI

  9. Bassit RA, Curi R, Costa Rosa LF. 2008. “Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE2 after a half-ironman competition.

    Amino Acids; 35(2):425–431. DOI

  10. Watanabe A, Kato N, Kato T. 2002. “Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.

    Neurosci Res; 42(4):279–285. DOI

  11. McMorris T, Harris RC, Swain J, Corbett J, Collard K, Dyson RJ, et al. 2006. “Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol.

    Psychopharmacology (Berl); 185(1):93–103. DOI

  12. Rae C, Digney AL, McEwan SR, Bates TC. 2003. “Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial.

    Proc R Soc B; 270(1529):2147–2150. DOI

  13. Kreider RB, Kalman DS, Antonio J, et al. 2017. “International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.

    J Int Soc Sports Nutr; 14:18. DOI

  14. Bogan KL, Brenner C. 2008. “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.

    Annu Rev Nutr; 28:115–130. DOI

  15. Tahiliani AG, Beinlich CJ. 1991. “Pantothenic acid in health and disease.

    Vitam Horm; 46:165–228. DOI

  16. Stover PJ, Field MS. 2015. “Vitamin B-6.

    Adv Nutr; 6(1):132–133. DOI

  17. Smith AD, Refsum H. 2016. “Homocysteine, B vitamins, and cognitive impairment.

    Annu Rev Nutr; 36:211–239. DOI

— 07 · FAQ p. 08
Common questions

Frequently asked.

Common questions about creatine, answered without jargon. Each answer reflects current peer-reviewed evidence and WELLF’s own R&D where relevant.

Pick’n’mix, with a PhD.